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KMID : 1002120080050010026
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Journal of Korean Sleep Research Society
2008 Volume.5 No. 1 p.26 ~ p.32
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Obstructive Sleep Apnea and Stroke; Cause or Consequence?
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Kim Yo-Sik
Park Hyun-Young
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Abstract
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Obstructive sleep apnea (OSA) is a common disorder which noted in 2-4% of general population. Patients considered it as a non-significant event and do not try to evaluate and treat it. The common manifestation of OSA is related to sleep fragmentation and is an excessive daytime sleepiness, decreased concentration, memory impairment and decreased job activity. Furthermore, OSA has negative effects on cardiovascular system. It increases prevalence and incidence of stroke and ischemic heart disease. OSA is associated with early neurological worsening and delay recovery from neurological deficit after stroke. OSA has negative effects on hypertension, platelet activation, fibrinogen, cardiac arrhythmia, endothelial function and IMT (intima-media thickness) in carotid artery. Treatment with continuous positive airway pressure (CPAP) has demonstrated reduction in risk factor abnormality and hope to decrease risk of cardiovascular events including stroke. However, OSA has not been considered as an independent risk factor for stroke, it needs conclusive evidence from well designed epidemiological studies.
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KEYWORD
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Obstructive sleep apnea, Stroke, Positive airway pressure
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